{"id":37097,"date":"2026-06-29T01:31:51","date_gmt":"2026-06-28T16:31:51","guid":{"rendered":"https:\/\/snakorea.info\/?p=37097"},"modified":"2026-06-29T01:31:51","modified_gmt":"2026-06-28T16:31:51","slug":"%ec%b0%a8%ec%84%b8%eb%8c%80%ec%9c%b5%ed%95%a9%ea%b8%b0%ec%88%a0%ec%97%b0%ea%b5%ac%ec%9b%90-%eb%b0%b1%ec%84%a0%ed%95%98-%ea%b5%90%ec%88%98-%ec%97%b0%ea%b5%ac%ed%8c%80-idh-%eb%8f%8c%ec%97%b0%eb%b3%80","status":"publish","type":"post","link":"https:\/\/snakorea.info\/?p=37097","title":{"rendered":"\ucc28\uc138\ub300\uc735\ud569\uae30\uc220\uc5f0\uad6c\uc6d0 \ubc31\uc120\ud558 \uad50\uc218 \uc5f0\uad6c\ud300, IDH \ub3cc\uc5f0\ubcc0\uc774 \uc2e0\uacbd\uad50\uc885\uc758 \uc9c4\ud589\u2027\uc7ac\ubc1c \uba54\ucee4\ub2c8\uc998 \uaddc\uba85"},"content":{"rendered":"

(\uc67c\ucabd\ubd80\ud1300 \uc735\uae30\uc6d0 \ubc31\uc120\ud558 \uad50\uc218 \u2024 \ubb38\ud6a8\uc740 \ubc15\uc0ac, \ubbf8\uad6d \uc608\uc77c\ub300 \ub85c\uc6b8 \ubc84\ud559 \uad50\uc218 [\uc0ac\uc9c4=\ucc28\uc138\ub300\uc735\ud569\uae30\uc220\uc5f0\uad6c\uc6d0]<\/p>\n

\u3010\uacbd\uae30·\ub0a8\ubd80 = \uc11c\uc6b8\ub274\uc2a4\ud1b5\uc2e0\u3011 \uae40\uc778\uc885 \uae30\uc790 = \uacbd\uae30\ub3c4·\uc11c\uc6b8\ub300\ud559\uad50 \uacf5\ub3d9\ucd9c\uc5f0\ubc95\uc778 \ucc28\uc138\ub300\uc735\ud569\uae30\uc220\uc5f0\uad6c\uc6d0(\uc6d0\uc7a5 \uae40\uc5f0\uc0c1, \uc774\ud558 \uc735\uae30\uc6d0)\uc740 \uc11c\uc6b8\ub300 \uc758\uacfc\ub300\ud559 \ubc31\uc120\ud558 \uad50\uc218\uac00 \uc774\ub044\ub294 \ub1cc\uc2e0\uacbd\uacf5\ud559 \ubc0f \ub098\ub178\uc758\ud559 \uc5f0\uad6c\uc2e4\uc5d0\uc11c \uae00\ub85c\ubc8c \uacf5\ub3d9\uc5f0\uad6c\ub97c \ud1b5\ud574 \ub09c\uce58\uc131 \ub1cc\uc885\uc591\uc758 \uc9c8\ubcd1 \uc9c4\ud589\uacfc \uc7ac\ubc1c \uacfc\uc815\uc744 \uaddc\uba85\ud558\ub294 \uc5f0\uad6c\uc131\uacfc\ub85c \uc138\uacc4 \ucd5c\uace0 \uad8c\uc704 \ud559\uc220\uc9c0 \u300c\ub124\uc774\ucc98(Nature)\u300d(IF:48.5) 6\uc6d4\ud638\uc5d0 \ub17c\ubb38\uc744 \uac8c\uc7ac\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

\uc774\ubc88 \uc5f0\uad6c\ub294 \uc735\uae30\uc6d0 \ubc31\uc120\ud558 \uad50\uc218(\uc11c\uc6b8\ub300\ud559\uad50\ubcd1\uc6d0 \uc2e0\uacbd\uc678\uacfc), \ubb38\ud6a8\uc740 \ubc15\uc0ac \ubc0f \ubbf8\uad6d \uc608\uc77c\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uc2e0\uacbd\uc678\uacfc(\ub85c\uc6b8 \ubc84\ud559 \uad50\uc218), \ubbf8\uad6d \ub9c8\uc774\uc560\ubbf8\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559, \ubbf8\uad6d \ud558\ubc14\ub4dc\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \ub9e4\uc0ac\ucd94\uc138\uce20 \uc885\ud569\ubcd1\uc6d0, \uadf8\ub9ac\uace0 \uc774\uc2a4\ub77c\uc5d8 \uc640\uc774\uc988\ub9cc \uc5f0\uad6c\uc18c\uac00 \ucc38\uc5ec\ud55c ‘\uc138\ud3ec \ub0b4\uc131 \ubc0f \uc9c4\ud654 \ubd84\uc11d(Cellular Analysis of Resistance and Evolution; CARE)’ \ucee8\uc18c\uc2dc\uc5c4\uc774 \uc9c4\ud589\ud55c \uacf5\ub3d9\uc5f0\uad6c \uc131\uacfc\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc740 \uc9c0\ub09c\ud574 \ub1cc\uc885\uc591 \uc911 \uac00\uc7a5 \uc545\uc131\uc778 ‘\uad50\ubaa8\uc138\ud3ec\uc885’\uc758 \uc9c4\ud654 \uada4\uc801\uc744 \ubc1d\ud600 \u300c\ub124\uc774\ucc98 \uc81c\ub124\ud2f1\uc2a4(Nature Genetics)\u300d\uc5d0 \ub17c\ubb38 2\ud3b8\uc744 \uc5f0\uc18d \uac8c\uc7ac\ud55c \ub370 \uc774\uc5b4, \uc62c\ud574 \uc138\uacc4 \ucd5c\uace0 \uad8c\uc704\uc758 \u300c\ub124\uc774\ucc98(Nature)\u300d \ubcf8\uc9c0\uc5d0 \uc5f0\ub2ec\uc544 \uc131\uacfc\ub97c \uc62c\ub9ac\uba70 \uae00\ub85c\ubc8c \uc5f0\uad6c \uc5ed\ub7c9\uc744 \ub2e4\uc2dc \ud55c\ubc88 \uc785\uc99d\ud588\ub2e4.<\/p>\n

\uc774\ubc88 \ub17c\ubb38 \uba85\uc740 ‘Acquired genetic and cell-state changes in IDH-mutant glioma progression’ (Johnson KC. et. al., Nature, June 2026)\uc774\uba70, \uc5f0\uad6c\ud300\uc740 \uc774\uc18c\uc2dc\ud2b8\ub808\uc774\ud2b8 \ud0c8\uc218\uc18c\ud6a8\uc18c(isocitrate dehydrogenase, IDH) \ub3cc\uc5f0\ubcc0\uc774 \uc2e0\uacbd\uad50\uc885\uc778 ‘\ud76c\uc18c\ub3cc\uae30\uc138\ud3ec\uc885(oligodendroglioma)’\uacfc ‘\uc131\uc0c1\uc138\ud3ec\uc885(astrocytoma)’\uc758 \uc9c8\ubcd1 \uc9c4\ud589 \uacfc\uc815\uc5d0\uc11c \uc138\ud3ec \uc0c1\ud0dc\ub97c \ud615\uc131\ud558\ub294 \ub0b4\u2027\uc678\uc801 \uc694\uc778\uc744 \ucd94\uc801\ud558\ub294 \ud1b5\ud569 \ubaa8\ub378\uc744 \uc81c\uc2dc\ud558\uace0 \ub2e8\uc77c \uc138\ud3ec \uae30\ubc18\uc73c\ub85c \uc720\uc804\uccb4\ub97c \ubd84\uc11d\ud558\ub294 \ucd5c\ucca8\ub2e8 \uc5f0\uad6c\ub97c \uc218\ud589\ud588\ub2e4.<\/p>\n

IDH1 \ubc0f IDH2 \uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774\ub294 \ubd84\uc790\uc801, \uc870\uc9c1\ud559\uc801, \uc784\uc0c1\uc801 \ud2b9\uc9d5\uc774 \ub69c\ub837\ud55c \uc131\uc778\ud615 \ubbf8\ub9cc\uc131 \uc2e0\uacbd\uad50\uc885\uc73c\ub85c, IDH \ub3cc\uc5f0\ubcc0\uc774 \uc2e0\uacbd\uad50\uc885\uc740 \uc138\uacc4\ubcf4\uac74\uae30\uad6c(WHO) \ubd84\ub958\uc5d0 \ub530\ub77c \ud76c\uc18c\ub3cc\uae30\uc138\ud3ec\uc885\uacfc \uc131\uc0c1\uc138\ud3ec\uc885\uc758 \ub450 \uac00\uc9c0 \uc720\ud615\uc73c\ub85c \ub098\ub25c\ub2e4. \ub450 \uc885\uc591 \ubaa8\ub450 \uc218\uc220\uc801 \uc808\uc81c, \ud56d\uc554 \ud654\ud559\uc694\ubc95, \ubc29\uc0ac\uc120 \uce58\ub8cc\uc5d0\ub3c4 \uc7ac\ubc1c\uc774 \uc7a6\uc544 \uce58\ub8cc\uac00 \uc5b4\ub835\uace0 \uc0ac\ub9dd\ub960\uc774 \ub192\uc740 \ub09c\uce58\uc131 \ub1cc\uc885\uc591\uc774\ub2e4. \uae30\uc874 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uce58\ub8cc \uc800\ud56d\uc131\uc758 \uc6d0\uc778\uc73c\ub85c \uc885\uc591 \ub0b4 \uc138\ud3ec \uc774\uc9c8\uc131, \ud6c4\ucc9c\uc801 \uc720\uc804\u2027\ud6c4\uc131\uc720\uc804\uc801 \uc774\uc0c1, \uadf8\ub9ac\uace0 \uace8\uc218 \uc138\ud3ec \uc9d1\ub2e8\uc758 \ubcc0\ud654 \ub4f1 \ubcf5\ud569\uc801\uc73c\ub85c \uc791\uc6a9\ud560 \uac00\ub2a5\uc131\uc774 \uc81c\uae30\ub418\uc5b4 \uc654\ub2e4.<\/p>\n

\uc774\uc5d0 \ub530\ub77c \uc774\ub7ec\ud55c \uc694\uc778\ub4e4\uc774 \uc885\uc591\uc758 \uc9c4\ud654\uc640 \uc7ac\ubc1c\uc5d0 \uc5b4\ub5a4 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0 \uaddc\uba85\ud558\ub294 \uac83\uc774 \ubcf4\ub2e4 \ud6a8\uacfc\uc801\uc778 \uce58\ub8cc \uc804\ub7b5 \uac1c\ubc1c\uc5d0 \ud544\uc218\uc801\uc774\ub2e4.<\/p>\n

\uc774\uc5d0 \uacf5\ub3d9\uc5f0\uad6c\ud300\uc740 \ub2e8\uc77c \ud575 RNA \uc2dc\ud038\uc2f1(snRNA-seq), \ub2e8\uc77c \ud575 \ud06c\ub85c\ub9c8\ud2f4 \uc811\uadfc\uc131 \ubd84\uc11d(snATAC-seq), \ub300\ub7c9 DNA\u2027RNA \uc2dc\ud000\uc2f1(DNA-seq, RNA-seq) \ub4f1 \ucd5c\ucca8\ub2e8 \uc720\uc804\uccb4 \ubd84\uc11d\uae30\uc220\uc744 \ud1b5\ud569 \uc801\uc6a9\ud55c \ud601\uc2e0\uc801 \ud504\ub808\uc784\uc6cc\ud06c\ub97c \uad6c\ucd95\ud588\ub2e4. \uc774\ub97c \ud1b5\ud574 35\uba85\uc758 \ud658\uc790\ub85c\ubd80\ud130 \uc218\uc9d1\ud55c 75\uac1c\uc758 \uc885\uc591 \uc0d8\ud50c\uc744 \uc815\ubc00 \ubd84\uc11d\ud558\uace0, \ud1b5\ud569\ub41c \ub370\uc774\ud130 \uc138\ud2b8\ub97c \ud1b5\ud574 IDH \ub3cc\uc5f0\ubcc0\uc774 \uad50\uc885\uc774 \uc9c8\ubcd1 \uc9c4\ud589 \uacfc\uc815\uc5d0\uc11c \ub530\ub974\ub294 \uada4\uc801 \ud30c\uc545 \ubc0f \uc545\uc131 \uc138\ud3ec \uc0c1\ud0dc\uac00 \ud6c4\uc131\uc720\uc804\ud559, \uc720\uc804\ud559, \ubbf8\uc138\ud658\uacbd \ubc0f \uce58\ub8cc\uc5d0 \uc758\ud574 \uc5b4\ub5bb\uac8c \ud615\uc131\ub418\ub294\uc9c0 \uaddc\uba85\ud588\ub2e4.<\/p>\n

\uc5f0\uad6c\uacb0\uacfc, IDH \ub3cc\uc5f0\ubcc0\uc774 \uc2e0\uacbd\uad50\uc885\uc758 \uc7ac\ubc1c\uacfc\uc815\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 \ud575\uc2ec \ubcc0\ud654\ub97c \ub2e4\uc74c\uacfc \uac19\uc774 \ubc1d\ud600\ub0c8\ub2e4.<\/p>\n

\uccab\uc9f8, IDH \ub3cc\uc5f0\ubcc0\uc774 \uc2e0\uacbd\uad50\uc885\uc740 \ub2e4\uc591\ud55c \uc138\ud3ec \uc0c1\ud0dc\ub85c \ubd84\ub958\ud560 \uc218 \uc788\ub2e4.<\/p>\n

\ub458\uc9f8, \uc885\uc591 \ub4f1\uae09\uc774 \uc545\uc131\ud654\ub420\uc218\ub85d \uc904\uae30\uc138\ud3ec\uc640 \uac19\uc740 \ubbf8\ubd84\ud654 \uc138\ud3ec\uac00 \uc99d\uac00\ud55c\ub2e4.<\/p>\n

\uc14b\uc9f8, \uc7ac\ubc1c \uacfc\uc815\uc5d0\uc11c \ud68d\ub4dd\ud55c \uc720\uc804\uc801 \uc774\uc0c1\uc774 \uc885\uc591\uc744 \ub354\uc6b1 \ubbf8\ubd84\ud654\ud558\uace0 \uacf5\uaca9\uc801\uc73c\ub85c \ub9cc\ub4e0\ub2e4. \uc774\ub7ec\ud55c \ubcc0\uc774\uc5d0\ub294 \uce58\ub8cc \uad00\ub828 \uacfc\ubcc0\uc774(hypermutation), \uc720\uc804\uc790 \ubcf5\uc81c \uc218(copy number) \ubcc0\ud654 \uc99d\uac00 \ubc0f \uc138\ud3ec \uc8fc\uae30(cell cycle) \ubcc0\ud654\uac00 \ud3ec\ud568\ub41c\ub2e4.<\/p>\n

\ub137\uc9f8, \uc911\uac04\uc5fd \uc720\uc0ac \uc0c1\ud0dc(mesenchymal-like-state)\uc758 \ud48d\ubd80\ub3c4 \uc99d\uac00\ub294 \ud68d\ub4dd\ub41c \uc720\uc804\uc801 \ubcc0\uc774\uc640\ub294 \ubb34\uad00\ud558\uac8c \ubc1c\uc0dd\ud588\uc73c\uba70, \uc624\ud788\ub824 \ub300\uc2dd\uc138\ud3ec(macrophage) \ubc1c\ud604 \uc99d\uac00\uc640 \uc77c\uce58\ud588\ub2e4.<\/p>\n

\uacb0\uacfc\uc801\uc73c\ub85c IDH \ub3cc\uc5f0\ubcc0\uc774 \uc2e0\uacbd\uad50\uc885\uc758 \uc7ac\ubc1c\uacfc \uc545\uc131\ud654\ub294 ‘\uc720\uc804\uc801 \uc9c4\ud654(Genetic evolution)’\uc640 ‘\uc885\uc591 \ubbf8\uc138\ud658\uacbd \ubcc0\ud654(Microenvironment evolution)’\ub77c\ub294 \ub450 \uc694\uc778\uc774 \ub3d9\uc2dc\uc5d0 \uc791\uc6a9\ud55c \uacb0\uacfc\ub77c\ub294 \uac83\uc774 \uc774\ubc88 \uc5f0\uad6c\uc758 \ud575\uc2ec\uc774\ub2e4. (\ubd99\uc784 1)<\/p>\n

\uc735\uae30\uc6d0 \ubc31\uc120\ud558 \uad50\uc218\ub294 “\uc774\ubc88 \uc5f0\uad6c\ub294 IDH \ub3cc\uc5f0\ubcc0\uc774 \uc2e0\uacbd\uad50\uc885\uc758 \uc7ac\ubc1c\uc774 \uc720\uc804\uc801 \uc9c4\ud654\uc640 \uba74\uc5ed \ubbf8\uc138\ud658\uacbd \ubcc0\ud654\ub77c\ub294 \ub450 \ucd95\uc73c\ub85c \uc9c4\ud589\ub428\uc744 \uaddc\uba85\ud574, \ud45c\uc801\ud654\ub418\uace0 \uac1c\uc778\ud654\ub41c \uce58\ub8cc \uc804\ub7b5 \uac1c\ubc1c\uc744 \uc704\ud55c \uac15\ub825\ud55c \ub85c\ub4dc\ub9f5\uc744 \uc81c\uacf5\ud55c\ub2e4”\uba70, “\uc774\ub97c \ud1b5\ud574 \ub09c\uce58\uc131 \ub1cc\uc885\uc591\uc73c\ub85c \uc54c\ub824\uc9c4 \ud76c\uc18c\ub3cc\uae30\uc138\ud3ec\uc885 \ubc0f \uc131\uc0c1\uc138\ud3ec\uc885\uc758 \uce58\ub8cc \uac00\ub2a5\uc131\uc744 \ub192\uc774\ub294 \ub370 \ud06c\uac8c \uae30\uc5ec\ud560 \uac83”\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"

(\uc67c\ucabd\ubd80\ud1300 \uc735\uae30\uc6d0 \ubc31\uc120\ud558 \uad50\uc218 \u2024 \ubb38\ud6a8\uc740 \ubc15\uc0ac, \ubbf8\uad6d \uc608\uc77c\ub300 \ub85c\uc6b8 \ubc84\ud559 \uad50\uc218 [\uc0ac\uc9c4=\ucc28\uc138\ub300\uc735\ud569\uae30\uc220\uc5f0\uad6c\uc6d0] \u3010\uacbd\uae30·\ub0a8\ubd80 =…<\/p>\n","protected":false},"author":1,"featured_media":37096,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-37097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-conomy"],"featured_image_urls":{"full":["https:\/\/snakorea.info\/wp-content\/uploads\/2026\/06\/news_img_20260629013156_33655-1.png",600,273,false]},"post_excerpt_stackable":"

(\uc67c\ucabd\ubd80\ud1300 \uc735\uae30\uc6d0 \ubc31\uc120\ud558 \uad50\uc218 \u2024 \ubb38\ud6a8\uc740 \ubc15\uc0ac, \ubbf8\uad6d \uc608\uc77c\ub300 \ub85c\uc6b8 \ubc84\ud559 \uad50\uc218 [\uc0ac\uc9c4=\ucc28\uc138\ub300\uc735\ud569\uae30\uc220\uc5f0\uad6c\uc6d0] \u3010\uacbd\uae30·\ub0a8\ubd80 = \uc11c\uc6b8\ub274\uc2a4\ud1b5\uc2e0\u3011 \uae40\uc778\uc885 \uae30\uc790 = \uacbd\uae30\ub3c4·\uc11c\uc6b8\ub300\ud559\uad50 \uacf5\ub3d9\ucd9c\uc5f0\ubc95\uc778 \ucc28\uc138\ub300\uc735\ud569\uae30\uc220\uc5f0\uad6c\uc6d0(\uc6d0\uc7a5 \uae40\uc5f0\uc0c1, \uc774\ud558 \uc735\uae30\uc6d0)\uc740 \uc11c\uc6b8\ub300 \uc758\uacfc\ub300\ud559 \ubc31\uc120\ud558 \uad50\uc218\uac00 \uc774\ub044\ub294 \ub1cc\uc2e0\uacbd\uacf5\ud559 \ubc0f \ub098\ub178\uc758\ud559 \uc5f0\uad6c\uc2e4\uc5d0\uc11c \uae00\ub85c\ubc8c \uacf5\ub3d9\uc5f0\uad6c\ub97c \ud1b5\ud574 \ub09c\uce58\uc131 \ub1cc\uc885\uc591\uc758 \uc9c8\ubcd1 \uc9c4\ud589\uacfc \uc7ac\ubc1c \uacfc\uc815\uc744 \uaddc\uba85\ud558\ub294 \uc5f0\uad6c\uc131\uacfc\ub85c \uc138\uacc4 \ucd5c\uace0 \uad8c\uc704 \ud559\uc220\uc9c0 \u300c\ub124\uc774\ucc98(Nature)\u300d(IF:48.5) 6\uc6d4\ud638\uc5d0 \ub17c\ubb38\uc744 \uac8c\uc7ac\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \uc735\uae30\uc6d0 \ubc31\uc120\ud558 \uad50\uc218(\uc11c\uc6b8\ub300\ud559\uad50\ubcd1\uc6d0 \uc2e0\uacbd\uc678\uacfc), \ubb38\ud6a8\uc740 \ubc15\uc0ac \ubc0f \ubbf8\uad6d \uc608\uc77c\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uc2e0\uacbd\uc678\uacfc(\ub85c\uc6b8 \ubc84\ud559 \uad50\uc218), \ubbf8\uad6d \ub9c8\uc774\uc560\ubbf8\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559, \ubbf8\uad6d \ud558\ubc14\ub4dc\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \ub9e4\uc0ac\ucd94\uc138\uce20 \uc885\ud569\ubcd1\uc6d0, \uadf8\ub9ac\uace0 \uc774\uc2a4\ub77c\uc5d8 \uc640\uc774\uc988\ub9cc \uc5f0\uad6c\uc18c\uac00 \ucc38\uc5ec\ud55c ‘\uc138\ud3ec \ub0b4\uc131 \ubc0f \uc9c4\ud654 \ubd84\uc11d(Cellular Analysis of Resistance and Evolution; CARE)’ \ucee8\uc18c\uc2dc\uc5c4\uc774 \uc9c4\ud589\ud55c \uacf5\ub3d9\uc5f0\uad6c \uc131\uacfc\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc9c0\ub09c\ud574 \ub1cc\uc885\uc591 \uc911…<\/p>\n","category_list":"\uacbd\uc81c<\/a>","author_info":{"name":"admin","url":"https:\/\/snakorea.info\/?author=1"},"comments_num":"0 comments","yoast_head":"\n\ucc28\uc138\ub300\uc735\ud569\uae30\uc220\uc5f0\uad6c\uc6d0 \ubc31\uc120\ud558 \uad50\uc218 \uc5f0\uad6c\ud300, IDH \ub3cc\uc5f0\ubcc0\uc774 \uc2e0\uacbd\uad50\uc885\uc758 \uc9c4\ud589\u2027\uc7ac\ubc1c \uba54\ucee4\ub2c8\uc998 \uaddc\uba85 - 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